3 Questions: On biology and medicine’s “data revolution”
Professor Caroline Uhler discusses her work at the Schmidt Center, thorny problems in math, and the ongoing quest to understand some of the most complex interactions in biology.
Broad Institute
How to more efficiently study complex treatment interactions
A new approach for testing multiple treatment combinations at once could help scientists develop drugs for cancer or genetic disorders.
New AI system uncovers hidden cell subtypes, boosts precision medicine
CellLENS reveals hidden patterns in cell behavior within tissues, offering deeper insights into cell heterogeneity — vital for advancing cancer immunotherapy.
Rationale engineering generates a compact new tool for gene therapy
Researchers redesign a compact RNA-guided enzyme from bacteria, making it an efficient editor of human DNA.
With AI, researchers predict the location of virtually any protein within a human cell
Trained with a joint understanding of protein and cell behavior, the model could help with diagnosing disease and developing new drugs.
An ancient RNA-guided system could simplify delivery of gene editing therapies
The programmable proteins are compact, modular, and can be directed to modify DNA in human cells.
A causal theory for studying the cause-and-effect relationships of genes
By sidestepping the need for costly interventions, a new method could potentially reveal gene regulatory programs, paving the way for targeted treatments.
A fast and flexible approach to help doctors annotate medical scans
“ScribblePrompt” is an interactive AI framework that can efficiently highlight anatomical structures across different medical scans, assisting medical workers to delineate regions of interest and abnormalities.
AI model identifies certain breast tumor stages likely to progress to invasive cancer
The model could help clinicians assess breast cancer stage and ultimately help in reducing overtreatment.
School of Engineering welcomes new faculty
Fifteen new faculty members join six of the school’s academic departments.